Cascade Metrix has innovated upon an automated blood sampling system and analytical platform ("AutoSampler") that is designed to enable increased adoption of multiple POC medical diagnostic applications currently constrained by workflow challenges stemming from manual blood sampling methods. To obtain a rapid blood analysis, a specimen is either rushed to a laboratory for an in vitro “stat” determination or it is tested at the “point-of care” with a portable analyzer or hand-held device. CM will soon introduce a revolutionary ex-vivo blood analysis system. The AutoSampler automatically samples micro-liter quantities of whole blood from a patient and performs frequent measurements of various blood constituents without wasting a single drop of blood. The CM system introduces a whole new paradigm in patient monitoring that will both optimize nursing efficiency and improve patient care. The platform is enabling the commercialization of multiple products.

CM's technology features the following:

  • Integrates a proprietary blood sampling methodology with a clinically proven electrochemical sensor system
  • Uses the latest in microfluidics and microelectronics, making the system both safe for the patient and intuitive to clinicians
  • Is designed to be as familiar to set-up and use as modern infusion devices, making the product easily adapt into any hospital environment
  • Displays measurement histories and trends and other data at a touch, all of which will interface with existing patient monitors/hospital information systems
  • Over time, the automated blood sampling platform will be utilized to develop a range of patient monitoring and control system

Product Pipeline

Multiple Blood Analytes: CM plans to add other time sensitive tests to the AutoSampler platform. Whole blood sensors to monitor sepsis, heparin therapy, blood gases, electrolytes and certain biomarkers will be integrated to the CM sampling platform. Combining leading edge innovations in micro-fluidics, electro-chemistry, and machine intelligence, CM has developed patentable inventions covering technologies, designs, and other relevant operational aspects.

Novel Micro-volume IV Extension Kits: This product will be a revenue Generator in the $1.5B IV Catheter Market. The extension kit lowers the blood loss per draw by an order of magnitude (from current 3-5ml to 0.3-0.5ml with proposed set). The extension kit consists of specialized zero dead volume snap-on luer, a self-sealing aseptic quick release mechanism that eliminates the need for manual pinch valves, smooth pressure-relieving external contours on the luer and quick release, and a small bore specialized kink resistant tubing with see-through fluidic components.

Technology Development History

Over the years, Cascade Metrix has developed multiple technologies for glucose sensing and automated blood sampling. The picture below gives a snapshot of the various technologies developed and prototyped by CM, starting with mid infrared quantum cascade laser spectroscopy based glucose sensors to a version that uses electrochemical sensors from BST Bio Sensor Technology, GmbH


CM's transition from infrared spectroscopy to electrochemistry based sensing was described in a research article published with the Journal of Diabetes Science and Technology

CAUTION: Investigational device, limited by federal law to investigational use.